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KMID : 0376219830200020309
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Chonnam Medical Journal
1983 Volume.20 No. 2 p.309 ~ p.318
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Antibacterial Activity of Chloramphenicol Combined with Other Bactericidal Antibiotics against Salmonella typhi and Shigella strains
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安泰然/Ahn, Tai Hew
黃京診/辛富安/流必悅/Whang, Kyung Chin/Shin, Boo Ahn/Rhyu, Phil Youl
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Abstract
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Bacteriostatic antibiotics may usually be accepted as interfering the activity of bactericidal drugs. Chloramphenicol(CM) is one of the well-known growth-inhibiting antibiotics so far frequently reported as acting antagonistically with beta-lactam antibiotics. However, studies reported have yielded conflicting results regarding the activity of combinations of CM and Ampicillin(AP) against Haemophilus influenzae. Conclusions have varied, suggesting from antagonistic effect to synergy.
Typhoid fever and bacterial dysentery are still endemic diseases in Korea. Some CM-resistant strains(S. typhi; 7, Shig. flexure 5, and Shig. sonnei 5) were chosen among recent isolates of the causative agents, and submitted to the present experiment to see what effect CM combined with AP, fosfomycin(FM), or talampicillin(TP) would have on the antibacterial activity of the combinations, using checkerboard dilution method and calculating the fractional inhibition concentration index(FICI) through isobologram. The results obtained were as follows.
Drug combination of CM ? FM had a marked growth inhibitory effect on most of the strains, exhibiting 35% synergism, 59% addtion, and 6 % indifference.
CM ? AP showed a wide range in the distribution of growth inhibition rates, synergism being 6%, addition 35%, indifference 53%, and antagonism 60/60. CM . TP, however, revealed the least effective activity, antagonism being 12%, indifference 65%, addition 23%, and synergism none.
No particular relationship was observed between the degree of antibiotic resistance and efficiency of the combined drugs.
It is, thus, suggested that CM may not necessarily act antagonistically with bactericidal antibiotics regardless of the species and antibiotic susceptibility degree of the strains employed.
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